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我院自1974年起采用天花粉粗制品引产,因副反应大、药源困难、保存期短而停用。但由于孕12～16周羊膜腔穿刺困难,仍显示该法的优越性。1987年起改用结晶天花粉针,主成分天花粉蛋白,分子量24000,有抗原性,对绒毛滋养叶细胞有专一作用,可使其变性坏死,绒毛间隙闭塞,纤维素沉着,血循环阻断,致胎儿死亡而流产。目前还扩大应用到滋养叶细胞有关病的治疗,如过期流产、死胎、宫外孕、葡萄胎、腹腔妊娠等。
Our hospital since 1974, the use of TCS crude induction of labor, due to side effects, drug source difficulties, short shelf life disabled. However, due to pregnancy amniocentesis 12 to 16 weeks difficult, still shows the superiority of the law. Since 1987, the use of crystal TCS, the main component of trichosanthin, molecular weight 24000, antigenic, villous trophoblast cells have a specific role, can make it degeneration and necrosis, villous gap occlusion, cellulosis, blood circulation blocked, caused by Fetal death and abortion. Currently also extended to the treatment of trophoblast-related diseases such as miscarriage, stillbirth, ectopic pregnancy, hydatidiform mole, abdominal pregnancy and so on.