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顺铂在美国已成为应用最广的抗癌药物,其它的铂络合物及含铂族金属如铑、钯等金属络合物也发现具有较好的抗肿瘤性质,其中有些还被应用于临床.K?pf-Maier研究金属茂和茂铁(Ⅱ)化合物对于移植人类肿瘤于小鼠体内后的抗癌扩散活性,发现钛茂二氯化物及它的一些衍生物在接种人胸腺癌的小鼠中,能够抑制肿瘤70%的发展.这种抑制性在治疗结束后至少延续3周,与5-氟尿嘧啶的疗效相似.在试验移植的人肺癌时,这些化合物使肿瘤的生长降低60～70%,且在治疗结束后,肿瘤还会继续减小.钛茂络合物对结肠癌、乳癌和肺癌也具有显著抑制活性.对于结肠癌和直肠癌,大部分被试验的茂铁化合物能抑制肿瘤70～80%的生长;对于肺癌,这些化合物能很强地抑制肿瘤扩散.
Cisplatin has become the most widely used anticancer drug in the United States. Other platinum complexes and metal complexes containing platinum group metals such as rhodium, palladium and the like have also been found to have good antitumor properties, some of which have also been applied to Clinical .K? Pf-Maier study of metallocene and ferrocene (II) compounds for transplanted human tumors in mice after the anti-cancer proliferation activity and found that titanium dioxide dichloride and some of its derivatives in the vaccination of human thymic carcinoma Mice, can inhibit the development of 70% of the tumor.The inhibition of at least 3 weeks after the end of treatment is similar to the effect of 5-fluorouracil.In the test of human lung cancer transplanted, these compounds reduce the tumor growth of 60 ~ 70%, and the tumor will continue to decrease after the treatment is completed.The titanocene complex also has significant inhibitory activity on colon cancer, breast cancer and lung cancer.For colon cancer and rectal cancer, most of the tested ferrocene compounds can Inhibition of tumor growth of 70 to 80%; for lung cancer, these compounds can strongly inhibit tumor proliferation.