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目的：评价乙酰吉他霉素颗粒剂治疗细菌性感染的疗效。方法：轻、中型呼吸道感染，泌尿、生殖系感染，皮肤软组织感染１６２例。用乙酰吉他霉素颗粒剂治疗１０２例，男性５６例，女性４６例，年龄３８±ｓ１２ａ；用依托红霉素冲剂对照治疗６０例，男性３４例，女性２６例，年龄３６±１１ａ。２组受试者均采用口服给药。２种药成人剂量均为１．０ｇ／ｄ，儿童剂量均为２５～５０ｍｇ／（ｋｇ·ｄ），分３～４次服，疗程７～１０ｄ。结果：临床总有效率分别为７２％和６７％；致病菌清除率分别为７４％和６３％；不良反应率分别为１６％和３２％。结论：乙酰吉他霉素颗粒剂治疗轻、中型细菌性感染疗效好而且较安全。
Objective: To evaluate the efficacy of acetylglutamycin granules in the treatment of bacterial infections. Methods: mild to moderate respiratory tract infection, urinary and reproductive system infections, skin and soft tissue infections in 162 cases. There were 102 males and 56 females with age of 38 ± s12a treated with acetylglutamycin granules. There were 60 males and 34 females with 36 ± 11 years of age. The subjects in both groups were administered orally. The dosage of two kinds of drugs were both 1.0g / d and children’s dosage was 25-50mg / (kg · d). The dosage was 2 or 3 times for 7 ~ 10 days. Results: The total clinical effective rates were 72% and 67% respectively. The pathogenic bacteria clearance rates were 74% and 63% respectively. The adverse reaction rates were 16% and 32% respectively. CONCLUSION: Acetylskeptomycin is effective and safe for the treatment of mild and moderate bacterial infections.