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目的探讨生活方式干预及优思明联合二甲双胍治疗青春期多囊卵巢综合征(PCOS)的临床疗效。方法选择青春期PCOS患者72例在生活方式干预的同时随机分为两组:观察组36例采用优思明联合二甲双胍治疗,对照组36例仅口服优思明治疗,6个月后观察两组经过治疗后的月经规律情况、卵巢体积大小以及体重指数(BMI)、空腹血糖(FPG)、睾酮(T)、黄体生成素(LH)、卵泡刺激素(FSH)的变化情况。结果两组患者治疗后的临床症状得以不同程度改善,观察组患者卵巢体积减小、月经规律优于对照组,差异有统计学意义(P<0.05);观察组LH、FSH、T水平降低优于对照组,差异有统计学意义(P<0.05);BMI、FPG均有不同程度下降,与治疗前比较差异有统计学意义(P<0.05)。结论优思明联合二甲双胍及生活方式干预治疗能有效改善青春期PCOS患者的临床症状,是治疗青春期PCOS的较理想的方法。
Objective To investigate the clinical effects of lifestyle intervention and metformin combined with metformin on adolescent polycystic ovary syndrome (PCOS). Methods 72 cases of adolescent PCOS patients were randomly divided into two groups at the same time of lifestyle intervention: 36 cases in the observation group were treated with Yasmin and metformin, 36 cases in the control group were treated with Yasmin only, and after 6 months, The menstrual regularity after treatment, the ovarian volume, the body mass index (BMI), fasting blood glucose (FPG), testosterone (T), luteinizing hormone (LH) and follicle stimulating hormone (FSH) Results The clinical symptoms of the two groups were improved to some extent after treatment. The ovarian volume and the regularity of menstruation in the observation group were better than those in the control group (P <0.05). The levels of LH, FSH and T in the observation group decreased significantly In the control group, the difference was statistically significant (P <0.05); BMI and FPG both decreased to some extent, with statistical significance (P <0.05). Conclusion You Siming combined with metformin and lifestyle interventions can effectively improve the clinical symptoms of adolescent PCOS patients is the treatment of adolescent PCOS more ideal way.