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总结保留幽门的胰十二指肠切除术（ＰＰＰＤ）治疗壶腹周围癌的临床效果。方法：将４７例ＰＰＰＤ与同期１２７例经典的胰十二指肠切除术（ＰＤ）作对照研究，分析两组的术后并发症及生存率。结果：ＰＰＰＤ组与ＰＤ组术后并发症发生率分别为３４．０％和２７．６％，其中胃排空延迟发生率分别为８．５％及６．３％，均无显著差异；术后５年生存率分别为４７．３％和４１．４％，无统计学差异。Ⅰ、Ⅱ期肿瘤的５年生存率为５９．３％，而Ⅲ、Ⅳ期肿瘤５年生存率仅为６．８％，两者差异显著（Ｐ＜０．０１）。结论：对于无明显胰外浸润转移的胰头癌及壶腹部癌患者可施行ＰＰＰＤ。
To summarize the clinical effects of pylorus-preserving pancreatoduodenectomy (PPPD) in the treatment of periampullary cancer. Methods: Forty-seven cases of PPPD were compared with 127 cases of classic pancreatoduodenectomy (PD) in the same period. The postoperative complications and survival rates of the two groups were analyzed. Results: The incidence of postoperative complications in PPPD group and PD group was 34.0% and 27.6%, respectively, and the delayed gastric emptying rate was 8.5% and 6.3%, respectively. There was no significant difference; The 5-year survival rate was 47.3% and 41.4%, respectively, with no statistical difference. The 5-year survival rate of stage I and II tumors was 59.3%, while the 5-year survival rate of stage III and IV tumors was only 6.8%. There was a significant difference between them (P<0.01). CONCLUSIONS: PPPD can be performed in patients with pancreatic head cancer and ampulla cancer without significant extrapancreatic invasion and metastasis.