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快原子轰击(fast atom bombardment,简称 FAR)质谱是八十年代开发的质谱新技术.这种在室温条件下用具有一定能量的中性原子轰击样品进行离子化的技术特别适用予热稳定性差、难挥发、强极性样品的分析.我们用 FAB 对七个暗霉素(nebramycin)抗生素组分进行结构测定,获得了较满意的结果.暗霉素属氨基糖苷类抗生素.我们从我国土壤中分离的菌株发酵液中提取暗霉素复合物及其水解产物,并分离和鉴定了七个单一组分.这七个化合物(1～7)的结构如下:
Fast atom bombardment (FAR) mass spectrometry is a new mass spectrometry technology developed in the 1980s. This technique of bombarding a sample with neutral energy with a certain energy at room temperature is especially suitable for the application with poor thermal stability, Difficult to volatilize, the analysis of the strong polar sample.We used FAB to carry on the structure determination of seven antibiotics components of nebramycin, obtained the satisfactory result.Amycin is an aminoglycoside antibiotic.We from our country soil The isolated strain of fermentation broth extract of the compound and its hydrolysis products, and separated and identified seven single components.The seven compounds (1-7) the structure is as follows: