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猪去氧胆酸(1)是我国甾体资源之一,它和有生理活性的鹅去氧胆酸(2),熊去氧胆酸(3)在结构上十分相似。从猪去氧胆酸(1)合成2和3的关键是保留A/B环顺式稠合,同时使6α-羟基移位成7α-或7β-羟基。文献报道
Hyodeoxycholic acid (1) is one of the steroid resources in China. It is very similar in structure to physiologically active chenodeoxycholic acid (2) and ursodeoxycholic acid (3). The key to the synthesis of 2 and 3 from hyodeoxycholic acid (1) is to preserve the A / B loop cis-condensation while displacing the 6 [alpha] -hydroxyl to 7 [alpha] - or 7 [beta] -hydroxy. Reported in the literature