临床上被诊断为暴发性肝炎的急重型肝炎常危及人的生命．病肝在早期表现为广泛融合的实质性坏死萎缩窦状结构，中期，可见到胆管和胆小管增生，最后，再生小结分化，导致坏死后有肝硬化．在肝纤维化中，产生细胞外基质的主要细胞是位于disse腔中的伊东细胞．另一方面，在汇管区 Severe hepatitis clinically diagnosed as fulminant hepatitis often endangers human life. In the early stage, the diseased liver showed substantial necrosis and atrophy of sinusoids in a wide range of fusion. In the medium-term, bile duct and cholangioderma proliferate. Finally, the regenerative nodules differentiate and cause cirrhosis after necrosis. In liver fibrosis, the major cells that produce the extracellular matrix are the Ito-cells located in the disse cavity. On the other hand, in the portal area