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目的总结男性乳腺癌(male breast cancer,MBC)的病因、治疗等方面的研究进展。方法通过阅读文献的方法,对MBC的病因、治疗等进行综述。结果家族史、乳腺癌易感蛋白1/2(BRCA1/2)基因突变、雌雄激素水平不平衡等众多因素是导致MBC发生的危险因素。前哨淋巴结活检(sentinel lymph node biopsy,SLNB)在MBC患者中具有可行性。放疗可以控制MBC的局部复发,化疗可能对远期生存率有益。MBC的内分泌治疗原则不能完全等同于女性乳腺癌(female breast cancer,FBC)。结论 MBC的危险因素众多,放化疗及内分泌治疗均可使MBC患者获益,但仍需大样本、高质量的临床研究论证。
Objective To summarize the research progress of the causes and treatment of male breast cancer (MBC). Methods By reading the literature, the etiology and treatment of MBC were reviewed. Results The family history, BRCA1 / 2 mutation and the imbalance of estrogen and androgen levels were the risk factors of MBC. Sentinel lymph node biopsy (SLNB) is feasible in MBC patients. Radiotherapy can control local recurrence of MBC and chemotherapy may be beneficial for long-term survival. The principle of endocrine therapy in MBC can not be completely equivalent to that of female breast cancer (FBC). Conclusions There are many risk factors for MBC. Chemotherapy, chemotherapy and endocrine therapy may benefit MBC patients. However, large sample and high quality clinical studies are still needed.