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目的：观察阿霉素脂质体（ＬＡＤＭ）经肝动脉给药对大鼠肝肿瘤的疗效，并与阿霉素水溶液（ＡＤＭ）及阿霉素加空白脂质体（ＡＤＭ＋ＢＬ）相比较．方法：应用改良逆相蒸发法制备ＬＡＤＭ，建立大鼠移植性Ｗ２５６肝癌模型并随机分为４组，经肝动脉分别灌注生理盐水，ＡＤＭ（２ｍｇ／ｋｇ），ＡＤＭ＋ＢＬ（２ｍｇ／ｋｇ）及ＬＡＤＭ（２ｍｇ／ｋｇ）．结果：与ＡＤＭ及ＡＤＭ＋ＢＬ组相比，经ＬＡＤＭ治疗的大鼠生存期显著延长（Ｐ＜００１），对肿瘤生长的抑制更为明显（Ｐ＜００１），肿瘤坏死更广泛、更彻底．结论：ＬＡＤＭ经肝动脉给药治疗肝癌疗效肯定，且优于ＡＤＭ与ＡＤＭ＋ＢＬ．
OBJECTIVE: To observe the effect of doxorubicin liposomal doxorubicin (LADM) administered via hepatic artery on hepatic tumor in rats, and compare it with adriamycin aqueous solution (ADM) and doxorubicin plus blank liposomes (ADM+BL). METHODS: LADM was prepared by modified reversed phase evaporation method. Rat model of transplanted W256 hepatocellular carcinoma was established and randomly divided into 4 groups. The hepatic artery was infused with normal saline, ADM (2 mg/kg), ADM+BL (2 mg/kg) and LADM. 2mg/kg). Results: Compared with ADM and ADM+BL group, the survival time of LADM-treated rats was significantly prolonged (P<001), and tumor growth was more significantly inhibited (P<001). Tumor necrosis was more extensive and more. thorough. Conclusion: The therapeutic effect of LADM by hepatic artery in treatment of liver cancer is positive and superior to that of ADM and ADM+BL.