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目的分析急性胰腺炎患者血浆瘦素水平的检验价值。方法将94例急性胰腺炎患者分为A组和B组,各47例。A组为刚入院患者,B组为已在本院接受2周生长抑素治疗患者,并选取同期健康体检人员40例,作为对照组。检测三组血浆瘦素、白细胞介素1β(IL-1β)、肿瘤坏死因子α(TNF-α)、白细胞介素4(IL-4)水平。结果 A组患者瘦素水平显著高于B组与对照组,差异有统计学意义(P<0.05),B组与对照组瘦素水平差异无统计学意义(P>0.05);A组与B组TNF-α水平均显著高于对照组,差异有统计学意义(P<0.05),A组与B组TNF-α水平对比差异无统计学意义(P>0.05)。三组IL-1β、IL-4组间对比差异无统计学意义(P>0.05)。结论血浆瘦素水平检验不仅能够用于急性胰腺炎患者的临床诊断,同时还可直接反映患者预后,应用价值显著。
Objective To analyze the value of plasma leptin in patients with acute pancreatitis. Methods 94 cases of acute pancreatitis were divided into group A and group B, 47 cases each. A group of patients just admitted to hospital, B group has been in our hospital for 2 weeks somatostatin treatment of patients, and select the same period, 40 health examination staff, as a control group. Plasma leptin, interleukin 1β (IL-1β), tumor necrosis factor α (TNF-α) and interleukin-4 (IL-4) levels were measured in three groups. Results The level of leptin in group A was significantly higher than that in group B and the control group (P <0.05), while there was no significant difference in leptin level between group B and control (P> 0.05) The levels of TNF-α in group A and group B were significantly higher than those in control group (P <0.05). There was no significant difference in TNF-α level between group A and group B (P> 0.05). There was no significant difference between the three groups of IL-1β, IL-4 (P> 0.05). Conclusion Plasma leptin level test can not only be used in clinical diagnosis of patients with acute pancreatitis, but also can directly reflect the prognosis of patients with significant value.