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目的探讨左归丸和戊酸雌二醇对骨质疏松牙周炎的治疗作用。方法 2007年10月至2009年3月在河北医科大学口腔医院选取纯种雌性6月龄SD大鼠36只,随机分为对照组、骨质疏松牙周炎组、西药组(戊酸雌二醇)、中药组(左归丸)4组,每组9只,建立骨质疏松牙周炎模型,按分组用药,于3个月时处死大鼠,取上颌骨标本,光镜下观察牙周组织病理变化,检测血清中的中碱性磷酸酶(ALP)、钙(Ca)、磷(P)。结果对照组牙周组织无明显变化;骨质疏松牙周炎组牙周炎症明显,牙槽骨大量吸收;西药组和中药组牙周炎症明显减轻,有牙槽骨新生。与骨质疏松牙周炎组相比,西药组和中药组血清中ALP降低(P<0.01),Ca升高(P<0.01),P降低(P<0.01)。结论左归丸和戊酸雌二醇均能减轻牙周炎症、抑制牙槽骨吸收,改善血清中骨代谢局部调节因子,促进颌骨骨量增加,改善牙槽骨结构。
Objective To investigate the therapeutic effect of Zuogui Pill and estradiol valerate on periodontitis with osteoporosis. Methods From October 2007 to March 2009, 36 purebred female 6-month-old SD rats were randomly divided into control group, osteoporosis periodontitis group, western medicine group (Zuogui Pill) 4 groups with 9 rats in each group. The models of periodontitis with osteoporosis were established. The rats were sacrificed at 3 months, the maxillary specimens were taken, and the teeth were observed under light microscope The histopathological changes were observed and the levels of ALP, Ca and P in serum were detected. Results There was no significant change in the periodontal tissue in the control group. The periodontal inflammation in the periodontitis group was obvious and the alveolar bone was absorbed in a large amount. The periodontal inflammation in the western medicine group and the traditional Chinese medicine group was significantly reduced, and alveolar bone was newborn. Compared with osteoporosis periodontitis group, the serum ALP in western medicine group and traditional Chinese medicine group decreased (P <0.01), Ca increased (P <0.01), P decreased (P <0.01). Conclusion Zuogui pill and estradiol valerate can both reduce periodontal inflammation, inhibit alveolar bone resorption, improve local metabolism of bone metabolism in serum, promote bone mass increase and improve alveolar bone structure.