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Objective: To explore whether the deletion (D) allele of angiotensin-converting enzyme (ACE) is associated with the risk or severity of bronchopulmonary dysplasia (BPD) among very low birth weight (BW) infants. Study design: Infants with a BW ≤1250 g were prospectively recruited. The D and I (insertion) alleles of ACE were determined using a polymerase chain reaction followed by restriction fragment length polymorphism analysis. Results: Infants with DDDI genotype of ACE had a (mean ±SD) birth weight (938 ±204 g vs 925 ±196 g) and gestational age (28 ±3 weeks vs 28 ±2 weeks), similar to infants with II genotype of ACE (P > .05). Infants with DDDI genotype of ACE were more likely to have BPD than infants with II genotype (47%vs 22%, P = .025). Among infants with BPD, ACE DDDI genotype was more common among infants with moderate or severe BPD compared with infants with mild BPD (74%vs 26%, P = .012). The number of D alleles of ACE correlated directly and positively with the severity of BPD (R = 0.23, P = .045). Conclusion: The D allele of ACE is associated with an increased risk and severity of BPD among preterm infants.
Objective: To explore whether the deletion (D) allele of angiotensin-converting enzyme (ACE) is associated with the risk or severity of bronchopulmonary dysplasia (BPD) among very low birth weight (BW) infants. Study design: Infants with a BW ≤ 1250 g were prospectively recruited. The D and I (insertion) alleles of ACE were determined using a polymerase chain reaction followed by restriction fragment length polymorphism analysis. Results: Infants with DDDI genotype of ACE had a (mean ± SD) birth weight (938 ± 204 g vs 925 ± 196 g) and gestational age (28 ± 3 weeks vs 28 ± 2 weeks), similar to infants with II genotype of ACE (P> .05). Infants with DDDI genotype of ACE were more likely to have Among the infants with BPD, ACE DDDI genotype was more common among infants with moderate or severe BPD compared with infants with mild BPD (74% vs 26%, P = .025) P = .012). The number of D alleles of ACE strongly directly and positively with the severi ty of BPD (R = 0.23, P = .045). Conclusion: The D allele of ACE is associated with an increased risk and severity of BPD among preterm infants.