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目的探讨地屈孕酮与黄体酮联合人绒毛膜促性腺激素(HCG)治疗先兆流产的临床疗效。方法将80例先兆流产患者采用随机数字表法分为研究组和对照组,每组40例。对照组患者给予黄体酮联合HCG治疗,研究组患者给予地屈孕酮联合HCG治疗。比较两组患者保胎成功率、临床症状消失时间、激素水平变化和不良反应发生率。结果研究组患者保胎成功率明显高于对照组,且止血时间和腰腹痛缓解时间均明显短于对照组,差异均有统计学意义(均P<0.05);两组患者治疗后孕激素和HCG水平均明显升高,但两组组间比较差异无统计学意义(P>0.05),研究组患者孕激素和HCG水平恢复时间均明显短于对照组,差异有统计学意义(P<0.01);研究组患者不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论地屈孕酮联合HCG治疗先兆流产起效更快,疗效更佳。
Objective To investigate the clinical efficacy of dydrogesterone combined with progesterone and human chorionic gonadotropin (HCG) in the treatment of threatened abortion. Methods Eighty cases of threatened abortion were divided into study group and control group by random number table method, 40 cases in each group. Patients in the control group were treated with progesterone plus HCG, and patients in the study group were treated with dydrogesterone combined with HCG. The success rate of miscarriage, the disappearance of clinical symptoms, the changes of hormone levels and the incidence of adverse reactions were compared between the two groups. Results The success rate of miscarriage in study group was significantly higher than that of control group, and the time to stop bleeding and the pain relief time were significantly shorter than those in control group (all P <0.05). After treatment, the progestin and HCG levels were significantly increased, but there was no significant difference between the two groups (P> 0.05), the recovery time of progesterone and HCG in the study group was significantly shorter than that in the control group, the difference was statistically significant (P <0.01 ). There was no significant difference in the incidence of adverse reactions between the study group and the control group (P> 0.05). Conclusion Dydrogesterone combined with HCG treatment of threatened abortion onset faster, better effect.