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1 促性腺激素释放激素(GnRH)1.1 GnRH 结构GnRH 是一短链氨基酸,由10个氨基酸(十肽)组成.第2、3位氨基酸对促性腺激素(Gns)释放有意义,而第1、6、10位则对维持空间结构和受体结合所必需.GnRH 脉冲式释放后迅速灭活,半寿期约5分钟,而脉冲周期为60～120分钟.1.2 GnRH 的生理作用1.21 下丘脑脉冲式释放GnRH:从垂体门脉取血证实,GnRH 呈间断性脉冲式释放,外周血浆中LH 和FSH 同样为脉冲样分泌模式,两者并有时间性关连.垂体对GnRH 的反应主要通过其频率的改变来调节,
1 GnRH 1.1 Structure of GnRH GnRH is a short chain amino acid consisting of 10 amino acids (decapeptides), while amino acids 2 and 3 are of significance for the release of gonadotropin (Gns) 6 and 10 are necessary for the maintenance of spatial structure and receptor binding.GnRH is rapidly inactivated after pulsed release with a half-life of about 5 minutes and a pulse period of 60 to 120 minutes.1.2 Physiological effects of GnRH 1.21 Hypothalamus pulse GnRH release from the pituitary portal vein confirmed GnRH intermittent pulsatile release of LH and FSH in the peripheral plasma is also a pulse-like secretion pattern, both of which are time-dependent.The response of the pituitary to GnRH mainly through its frequency The change to adjust,