论文部分内容阅读
术前单次应用甲硝哒唑肛门栓(1g)可有效地降低胃肠道穿孔性腹膜炎及急性阑尾炎术后切口感染率。我院对527例胃肠道穿孔性腹膜炎患者术前使用肛栓,使切口感染率由27.5%降至8.5%(P<0.05)。测得9名健康志愿者(男4,女5)及5名患者(男3,女2)的血清甲硝哒唑浓度,C_(max)分别为:男性志愿者15.62mg/L,女性志愿者11.88mg/L,患者10.53mg/L,表明体内药物已达到有效浓度,其它药动学参数(Ka、K、t_(max)、t_?)与文献接近,从而为临床单次应用甲硝哒唑肛门栓提供了实验依据。
Single preoperative application of metronidazole aniline suppository (1g) can effectively reduce perforation of gastrointestinal peritonitis and acute appendicitis incision infection rate. In our hospital, 527 cases of perforation peritonitis of the gastrointestinal tract were treated with anal suppository before operation, which reduced the incision infection rate from 27.5% to 8.5% (P <0.05). The serum concentrations of metronidazole in nine healthy volunteers (male 4, female 5) and 5 (male 3, female 2) were measured and their C max values were 15.62 mg / L for male volunteers, (11.88mg / L, 10.53mg / L), indicating that the in vivo drug has reached an effective concentration and the other pharmacokinetic parameters (Ka, K, t max, t_?) Are close to those in the literature, Pyrazole anal suppository provided experimental evidence.