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DNA折纸术(DNA origami)作为一种精确高效的自组装技术,自2006年Rothemund发明以来在生物医药、高灵敏度检测、纳米光电子器件、等离子体光子学等领域展现出巨大的应用潜力,近年来受到广大研究者的高度关注。利用DNA折纸术构建纳米材料是以DNA origami结构为载体,通过碱基互补配对的原则及三维结构上可程序化设计和可寻址的特点精确地组装很多功能基团如金属及半导体纳米颗粒,蛋白质和单壁碳纳米管等,并应用于研究无标记的RNA杂交检测、单分子的化学反应、检测间距对多价态的配位体-蛋白质之间键合的影响等。本文对近几年来DNA origami构建功能纳米材料的研究进展加以系统综述,并对DNA origami的发展方向和应用前景进行了展望。
As an accurate and efficient self-assembly technique, DNA origami has shown great potential in bio-medicine, high-sensitivity detection, nano-optoelectronics and plasma photonics since it was invented in 2006. In recent years By the majority of researchers attention. The use of DNA origami technology to construct nanomaterials uses DNA origami structure as a carrier. Precise assembly of many functional groups such as metal and semiconductor nanoparticles by the principle of complementary base pairing and three-dimensional structurally programmable design and addressable features, Proteins and single-walled carbon nanotubes, and applied to the study of unlabeled RNA hybridization detection, single-molecule chemical reactions, the detection of spacing on the multivalent state ligand-protein binding between the impact. In this paper, we review the recent progress in the research of DNA origami nanomaterials, and prospect the development direction and application prospects of DNA origami.