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通过Ｅｌｉｓａ检测内毒素ＤＩＣ家兔血浆肿瘤坏死因子α（ＴＮＦ－α）、白细胞介素６（ＩＬ－６）水平变化，并观察中药热毒清注射液对ＴＮＦ－α、ＩＬ－６水平的影响。结果发现，模型组血浆ＴＮＦ－α、ＩＬ－６水平显著升高，其升高水平和组织、器官的损害程度相一致。运用热毒清作为防治处理后，ＴＮＦ－α、ＩＬ－６水平显著降低，组织、器官的损害也相应较轻。以上结果提示ＴＮＦ－α、ＩＬ－６参与ＤＩＣ发病机制，中药热毒清通过降低ＴＮＦ－α、ＩＬ－６水平可能对ＤＩＣ具有防治作用。
The changes of plasma tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels in rabbits with endotoxin-induced DIC were measured by Elisa, and the effects of Chinese herbal medicine Duduqing injection on TNF-α and IL-6 levels were observed. . The results showed that plasma levels of TNF-α and IL-6 were significantly elevated in the model group, and the levels of elevated TNF-α and IL-6 were consistent with the degree of tissue and organ damage. The use of heat toxin as a control treatment, TNF-α, IL-6 levels were significantly reduced, the damage to tissues and organs is also relatively light. The above results suggest that TNF-α and IL-6 may participate in the pathogenesis of DIC, and that Chinese Herbal Hot Toxin may prevent and treat DIC by decreasing the levels of TNF-α and IL-6.