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目的观察外周血CD34+细胞与脑外伤患者预后关系。方法随访脑外伤患者6个月,用格拉斯哥昏迷评分(GCS),分为预后良好组和预后不良组。单因素分析比较2组入院时外周血CD34+细胞、格拉斯哥昏迷评分(GCS)及蛛网膜下腔出血、瞳孔散大、中线偏移、环池消失比例的差别。用Logistic多元回归分析外周血CD34+细胞与脑外伤患者预后的关系。结果预后良好组GCS评分显著高于预后不良组(P<0.01);预后良好组蛛网膜下腔出血、瞳孔散大、中线偏移、环池消失比例及外周性CD34+细胞数量显著低于预后不良组(均P<0.01)。GCS和外周血CD34+细胞均为脑外伤患者预后的影响因素。结论脑外伤患者外周血CD34+细胞水平升高,且其水平越高,患者预后越差。
Objective To observe the relationship between the peripheral blood CD34 + cells and the prognosis of traumatic brain injury. Methods The patients with traumatic brain injury were followed up for 6 months. The patients were divided into good prognosis group and poor prognosis group by Glasgow Coma Scale (GCS). Univariate analysis was used to compare the difference of CD34 + cells, Glasgow coma score (GCS) and subarachnoid hemorrhage, mydriasis, midline deviation and disappearance of peri-annular pool in admission. Logistic Multiple Regression Analysis of the Relationship between Peripheral Blood CD34 + Cells and the Prognosis of Patients with Traumatic Brain Injury. Results The GCS score of the good prognosis group was significantly higher than that of the poor prognosis group (P <0.01). In the good prognosis group, the subarachnoid hemorrhage, mydriasis, midline deviation, disappearance of peri-annular pool and the number of peripheral CD34 + cells were significantly lower than those with poor prognosis Group (all P <0.01). GCS and peripheral blood CD34 + cells are prognostic factors in patients with traumatic brain injury. Conclusion The levels of CD34 + cells in peripheral blood of patients with traumatic brain injury increase, and the higher the level, the poorer the prognosis of patients.