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血小板活化因子(PAF)是哮喘等疾病的一种炎症介质。作者对28例哮喘患者、7例肺气肿患者和11例对照者进行了支气管肺泡灌洗(BAL),用鲁米诺和光泽精放大化学发光方法进行细胞总数及其分类计数,并评价细胞代谢活性。用豚鼠测定BAL 上清液中PAF 和可溶性PAF(Lyso-PAF).后者是PAF 的主要代谢物,也是PAF 的主要前体。试图了解哮喘患者BAL 液中的PAF 与哮喘活动性和气道炎症的关系.PAF 在体内迅速代谢,在血液中其半衰期不足1分钟,但其主要代谢物可溶性PAF 较稳
Platelet-activating factor (PAF) is an inflammatory mediator of diseases such as asthma. Bronchial alveolar lavage (BAL) was performed in 28 asthmatic patients, 7 emphysematous patients and 11 controls, and the total number of cells and their differential counts were calculated using luminol and luminol chemiluminescence chemiluminescence and the cells were evaluated Metabolic activity. PAF and soluble PAF (Lyso-PAF) in BAL supernatants were measured in guinea pigs, the main metabolite of PAF and the primary precursor of PAF. In an attempt to understand the relationship between PAF in asthmatic BAL fluid and asthma activity and airway inflammation, PA rapidly metabolizes in the body with a half-life in the blood of less than one minute, but its main metabolite, soluble PAF, is more stable