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目的:调查医院门诊奥美拉唑处方,分析奥美拉唑与其他药物联合应用情况,为临床合理用药提供参考。方法:抽取常熟市中医院2010年1～12月含奥美拉唑的门诊处方,对患者的基本情况、与其他药物联合使用的频率及合理性等进行统计、分析。结果:一年内奥美拉唑口服剂处方2 787张,联合用药1 384张(49.7%);莫沙必利(瑞琪,354张)、曲美布汀(131张)、克拉霉素(含缓释片,148张)、阿莫西林(含复方制剂,89张)、多潘立酮(吗丁啉,61张)、铝碳酸镁片(达喜,56张)在联合用药中出现频率较高。结论:奥美拉唑门诊处方基本合理;与克拉霉素、多潘立酮、阿托伐他汀、阿司匹林等联用时,可能会发生不利的相互作用,提请临床避免联用或选择最佳药物,减少药物不良反应(ADR)发生;药师应认真做好处方审查、干预临床用药和窗口医嘱。
OBJECTIVE: To investigate prescriptions of omeprazole in outpatient departments of hospitals and analyze the combined application of omeprazole and other drugs to provide reference for clinical rational drug use. Methods: Outpatient prescriptions containing omeprazole from January to December 2010 in Changshu Hospital of Traditional Chinese Medicine were collected. The basic conditions of the patients, the frequency and rationality of the combination with other drugs were statistically analyzed. RESULTS: A total of 2 787 prescriptions of omeprazole oral agents were administered during the year, 1 384 (49.7%) were administered in combination, mosapride (354 Ruiqi), trimebutine (131), clarithromycin (Including 148 tablets), amoxicillin (89 tablets), domperidone (domperidone, 61 tablets) and aluminum magnesium carbonate tablets (up to 56 tablets) appeared more frequently in the combination therapy . Conclusion: Omeprazole outpatient prescriptions are basically reasonable; with dexamethasone, domperidone, atorvastatin, aspirin and other combinations, adverse interactions may occur, to prevent the combination of the clinical or choose the best drug to reduce drug abuse Response (ADR) occurs; pharmacists should do a good job censorship prescriptions to intervene in clinical medication and window doctor’s advice.