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目的：对医院新生儿病房多药耐药菌感染及对抗菌药物耐药性进行分析，为临床合理用药及降低医院感染发生率提供依据。方法对64例患儿的感染资料进行回顾性分析。结果64例患儿中肺炎45例，败血症10例，化脓性脑膜炎、泌尿系统感染及脐炎各3例；排名前3位的病原菌依次为肺炎克雷伯菌、大肠埃希菌、溶血葡萄球菌。结论多药耐药菌以医院感染病原菌为常见，主要感染部位为肺部、血液、泌尿道，应加强多药耐药菌监测与控制，合理应用抗菌药物，对早产儿、极低出生体重儿，应缩短住院时间，不主张预防性使用抗菌药物。“,”Objective To analysis multidrug-resistant infections and antimicrobial resistance of neonatal ward,and provide the basis for rational drug use and reducing the incidence of nosocomial infection.Methods 64 cases of children infected data were retrospectively analyzed.Results 45 cases of children with pneumonia,sepsis 10 cases,purulent meningitis,urinary tract infections and Omphalitis al three cases;The top three pathogens were Klebsiel a pneumoniae,Escherichia coli,Staphylococcus haemolyticus.Conclusion It is common that Multidrug-resistant pathogens exsited in hospital,and the main site of the lungs,blood,urinary tract.We should strengthen the monitoring and control of multidrug-resistant bacteria,and it does not advocate the use of prophylactic antibiotics.