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甾体(类固醇)激素是一类属于环戊烷多氢菲(Cyclopentanoperhydrophenanthrene)结构的化合物。它包括雌激素、孕激素、雄激素和类皮质激素。这些激素在生物效应上显示一个连续的、相对特异性的谱系。目前,临床上已能通过控制机体的甾体激素内环境(steroid hormone milieu),治疗乳腺癌、子宫内膜癌和前列腺癌。 早在1896年Beatson就报道用卵巢切除术治疗晚期乳腺癌,使病情获得缓解。直到1961年Fol-ca等第一次指出:乳腺癌细胞内存在一种与甾体激素起特异作用的机制,并提出受体(receptor)的概
Steroid (steroid) hormones are a class of compounds that are Cyclopentanoperhydrophenanthrene structures. It includes estrogens, progestins, androgens and corticosteroids. These hormones show a continuous, relatively specific lineage in biological effects. At present, it has been possible to treat breast cancer, endometrial cancer, and prostate cancer by controlling the body’s steroid hormone milieu. As early as 1896, Beatson reported using oophorectomy for advanced breast cancer to relieve the condition. Until 1961, Fol-ca et al. pointed out for the first time that there is a mechanism for a specific role of steroid hormones in breast cancer cells, and proposes the concept of receptors.