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[目的]探讨手臂振动对手部循环功能的影响及其与血管内皮活性物质之间的关系。[方法]以煤矿男性井下掘进工64名作为研究对象,按累积接振时间的长短分为高暴露组、中暴露组和低暴露组,并选22名非接振的健康人作为对照组,对每组进行血管内皮物质和冷水负荷试验测定,分析二者之间的相关关系。[结果]3个振动暴露组内皮素(ET)浓度、血栓素B2(TXB2)浓度均明显高于对照组(P<0.01);该3个暴露组的一氧化氮(NO)浓度、6-酮前列腺素F1α(6-keto-PGF1α)浓度均明显低于对照组(P<0.01)。冷水试验前高暴露组皮肤温度明显低于对照组(P<0.01),冷水负荷试验后3个暴露组在5、10、30min的皮肤温度明显低于相同时间的对照组(P<0.01)。10min复温异常率、30min复温异常率在对照组、低暴露组、中暴露组、高暴露组间差异有统计学意义(P<0.01);且呈明显的剂量-效应关系。将各组血管内皮物质与5min复温率、10min复温率进行相关分析,可见复温率与ET、TXB2呈明显的正相关关系(P<0.01),而与NO、6-keto-PGF1α呈明显的负相关关系(P<0.01)。[结论]振动性血管内皮物质紊乱与手部复温情况具有一致性,提示振动性血管功能紊乱可以作为振动性血管损伤的评价参考指标。
[Objective] To explore the influence of arm vibration on circulatory function of hand and its relationship with vascular endothelial active substances. [Method] Taking 64 underground tunneling workers in coal mines as the research objects, the cumulative duration of vibration was divided into high exposure group, medium exposure group and low exposure group, 22 healthy persons without vibration were selected as the control group, The vascular endothelial material and cold water load were tested in each group, and the correlation between them was analyzed. [Results] The endothelin (ET) and thromboxane B2 (TXB2) concentrations in the three exposed groups were significantly higher than those in the control group (P <0.01). The concentrations of nitric oxide (NO) The concentration of ketoprostaglandin F1α (6-keto-PGF1α) was significantly lower than that of the control group (P <0.01). The skin temperature of high exposure group before cold water test was significantly lower than that of control group (P <0.01). The skin temperature of 3 exposed groups after cold water load test at 5, 10 and 30 minutes was significantly lower than that of the control group at the same time (P <0.01). The anomalous rate of 10-minute rewarming and the abnormal rate of 30-minute rewarming were significantly different between the control group, the low-exposure group, the medium-exposed group and the high-exposed group (P <0.01), and showed a dose-response relationship. Correlation analysis showed that the rate of rewarming was positively correlated with ET, TXB2 (P <0.01), but not with NO, 6-keto-PGF1α Significant negative correlation (P <0.01). [Conclusions] Vibrational vascular endothelial dysfunction and hand rewarming conditions are consistent, suggesting that vasomotor dysfunction can be used as a reference value for the assessment of vascular injury.