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[目的]探讨Ⅱ期宫颈癌术前应用化放疗的临床价值。[方法]根据术前辅助方法不同分为3组 :术前介入组36例 ,术前介入加后装组24例 ,术前后装组21例 ,对各组的近期疗效、术后病理组织学变化进行比较。[结果]经术前介入或介入配合后装治疗宫颈局部肿瘤明显缩小 ,近期有效率分别达97 2%及100 % ,较术前后装组42 9 %明显提高(P<0 001) ;术后病理组织学比较 ,60例总的淋巴结转移率11 7 % ,深肌层浸润率10 0 % ,宫旁浸润率5 0 %及神经脉管侵犯率10 0 % ,均明显低于术前后装组的38 1%、42 9 %、42 9 %及42 9%(P<0 01)。[结论]术前辅以化、放疗对Ⅱ期宫颈癌疗效明显。
[Objective] To investigate the clinical value of preoperative chemoradiotherapy for stage Ⅱ cervical cancer. [Methods] According to the different preoperative adjuvant methods, the patients were divided into 3 groups: preoperative intervention group (n = 36), preoperative intervention plus afterloading group (n = 24), preoperative and postoperative group (n = 21) Learning changes compared. [Results] The local tumor of cervix was significantly reduced after preoperative intervention or after interventional treatment, the effective rates were 97 2% and 100% respectively, which were significantly higher than those of 42 9% before and after operation (P 0 001) The posterior histopathology showed that the total lymph node metastasis rate was 17.7%, deep myometrial invasion rate was 100%, uterine infiltration rate was 50% and nerve vessel invasion rate was 100% Group 38 1%, 42 9%, 42 9% and 42 9% (P <0.01). [Conclusion] Preoperative supplementation and radiotherapy have obvious curative effect on stage Ⅱ cervical cancer.