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目的评价口服降糖药物联合甘精胰岛素治疗2型糖尿病的临床疗效。方法对我院67例单用口服降糖药物效果欠佳的2型糖尿病患者,于睡前加用甘精胰岛素治疗,比较治疗前后空腹血糖(FPG)、餐后2 h血糖(2 h PG)、空腹C肽(FCP)、餐后2 h C肽(2 h CP)、糖化血红蛋白(HbA1c)及体质量指数(BMI)等指标与低血糖发生率。结果经治疗后,患者的FPG、2 h PG和HbA1c均较治疗前明显降低,而FCP、2 h CP均较治疗前有所升高,差异均有统计学意义(P<0.05)。结论口服降糖药物联合甘精胰岛素治疗2型糖尿病疗效明显且安全性较高,患者血糖能够得到较好的控制。
Objective To evaluate the clinical efficacy of oral hypoglycemic agents combined with insulin glargine in the treatment of type 2 diabetes mellitus. Methods A total of 67 patients with type 2 diabetes mellitus who did not receive oral hypoglycemic drugs were treated with insulin glargine before bedtime. Fasting plasma glucose (FPG), 2 h postprandial plasma glucose (2 h PG) , Fasting C-peptide (FCP), postprandial 2-h C peptide (2h CP), glycosylated hemoglobin (HbA1c), body mass index (BMI) and the incidence of hypoglycemia. Results After treatment, the FPG, 2 h PG and HbA1c in patients were significantly lower than those before treatment, while the FCP and 2 h CP were higher than those before treatment, the difference was statistically significant (P <0.05). Conclusion Oral hypoglycemic agents combined with insulin glargine treatment of type 2 diabetes with significant efficacy and safety of patients with blood glucose can be better controlled.