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N′-烷基烟酰胺是烟酸和烟酰胺在尿中的主要代谢产物,影响细胞内吡啶核苷酸的调节,其在尿中的含量与各种疾病状态有一定联系。本文报道了用高效液相色谱法测定尿中N′-烷基烟酰胺类(C_1～C_5烷基衍生物)的方法。仪器:用LC-2型色谱仪、填充剂为Zor-bax SCX-300(7～8 μm,Du Pont)的柱(15×0.46 cm.i.d)和
N’-alkylnicotinamide is the main metabolite of nicotinic acid and niacinamide in the urine and affects the regulation of intracellular pyridine nucleotide. The content in urine is related to various disease states. This article reports the determination of urinary N’-alkylnicotinamides (C 1 -C 5 alkyl derivatives) by high performance liquid chromatography. Instrumentation: A column (15 × 0.46 cm.i.d) of Zor-bax SCX-300 (7 to 8 μm, Du Pont) with a LC-2 chromatograph and