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人白细胞抗原 (ＨＬＡ) ＤＲβ1 0 40 1、 0 40 4和 0 40 5等亚型以及蛋白激酶Ａ(ＰＫＡ)信号异常在类风湿关节炎 (ＲＡ)发病中的作用已得到证明[1 3] 。然而 ,ＨＬＡ ＤＲβ1亚型与ＰＫＡ通路之间的关系尚不清楚。因此 ,我们研究了ＨＬＡ ＤＲβ1同源多肽对腺苷环化酶 (ＡＣ
The role of subtype HLA DRβ1 0 40 1, 0 40 4 and 0 40 5, and protein kinase A (PKA) signaling abnormalities in the pathogenesis of rheumatoid arthritis (RA) has been demonstrated [13]. However, the relationship between the HLA DRβ1 subtype and the PKA pathway remains unclear. Therefore, we studied the effect of HLA DRβ1 homologous polypeptides on adenylyl cyclase (AC