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据2015年4月25日《中国科学报》援引报道,武汉大学生科院宋保亮研究团队发现细胞内胆固醇运输的新途径,具有重要的基础和临床应用价值。成果刊登于《细胞》杂志。胆固醇是细胞内含量非常丰富的一类脂质分子,它的分布极不均匀且其运输处于高度动态,对维持细胞的正常生命活动至关重要。研究团队通过全基因组筛选,鉴定出300多个与胆固醇运输相关的基因;发现溶酶体通过和过氧化物酶体相互接触将胆固醇转移给后者;确认介导溶酶体与过氧化
According to the report of China Science News on April 25, 2015, the research group of Song Baoliang of Wuhan University’s CASS found new ways of intracellular cholesterol transport, which has important foundation and clinical application value. Results published in the “Cell” magazine. Cholesterol is a type of lipid molecule with a very rich intracellular content. Its distribution is extremely uneven and its transport is highly dynamic, which is crucial for maintaining the normal life activities of cells. The research team identified more than 300 genes related to cholesterol transport through genome-wide screening; found that lysosomes transferred cholesterol to the latter by interacting with peroxisomes; and confirming that lysosomes and peroxides