决奈达隆是一个新型的第Ⅲ类抗心律失常药物,其结构和作用机制与胺碘酮相近。决奈达隆不含碘,也不引起甲状腺功能异常和肺纤维化。一些研究表明决奈达隆有增加死亡率和加重心力衰竭等心血管事件的趋势,其原因尚不清楚,可能与心、肾功能恶化等有关,应慎用于中重度心力衰竭患者和永久性心房颤动患者。本文对决奈达隆对死亡率和心血管事件发生率的影响作一综述。 Dronedarone is a new class III anti-arrhythmic drug whose structure and mechanism of action are similar to that of amiodarone. Dronedarone does not contain iodine nor causes thyroid dysfunction and pulmonary fibrosis. Some studies have shown that dronedarone has increased mortality and worsen the trend of cardiovascular events such as heart failure, the reason is not clear, may be related to heart and kidney dysfunction, etc., should be used with caution in patients with moderate and severe heart failure and permanent Atrial fibrillation patients. This article reviews the impact of dronedarone on the incidence of mortality and cardiovascular events.