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为评价早期干预对改善新生儿缺氧缺血性脑病 (HIE)患儿智力发育的效果 ,以62例中、重度HIE患儿随机分为干预组30例和常规育儿组32例 ,另设同期正常新生儿30例为对照组。干预组从新生儿期开始接受为期24月～30月的以家庭为中心的干预治疗。所有病例均于生后每隔3月～6月进行智能发育检测。结果干预组1岁、2岁时智力发育指数 (MDI)、运动发育指数 (PDI)比常规育儿组高 (P<0.01) ,可达正常对照组水平 (P>0.05) ;干预组康复率为93 %,而常规育儿组仅为72 %,提示早期干预可促进HIE患儿智力发育 ,有效地防治HIE所致的后遗症。
To evaluate the effect of early intervention on improving mental development in neonates with hypoxic-ischemic encephalopathy (HIE), 62 patients with moderate and severe HIE were randomly divided into intervention group (n = 30) and routine parental group (n = 32) 30 normal newborns as control group. The intervention group received a family-centered intervention from 24 months to 30 months from the neonatal period. All cases were tested for intelligence development every 3 months to 6 months after birth. Results The mental development index (MDI) and motor development index (PDI) of the intervention group were higher than those of the normal parental group (P <0.01) at the age of 1 and 2 years old, reaching the level of the normal control group 93%, while only 72% of the conventional child care group, suggesting that early intervention can promote mental development in children with HIE, effective prevention and treatment of sequelae caused by HIE.