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目的探讨结直肠癌神经内分泌分化与结直肠癌预后的关系。方法对73例结直肠低分化腺癌的临床和随访资料进行回顾性分析,并应用免疫组化的方法检测嗜铬素A、突触素在肿瘤及转移淋巴结和远处转移组织的表达。结果73例结直肠低分化腺癌患者中有13例表现为神经内分泌分化(17.8%),且这组患者的1年生存率明显低于同时期的结直肠低分化腺癌组(P<0.05)。其转移淋巴结以及远处转移组织中以神经内分泌克隆为主。结论结直肠癌神经内分泌克隆是影响其淋巴结及远处组织转移的重要因素,它可能会成为判断结直肠癌预后的新的的指标及治疗靶点。
Objective To investigate the relationship between the neuroendocrine differentiation of colorectal cancer and the prognosis of colorectal cancer. Methods The clinical and follow-up data of 73 cases of colorectal poorly differentiated adenocarcinoma were retrospectively analyzed. The expressions of chromogranin A and synaptophysin in tumor, metastatic lymph node and distant metastasis were detected by immunohistochemistry. Results Thirteen of 73 patients with colorectal poorly differentiated adenocarcinoma showed neuroendocrine differentiation (17.8%), and the 1-year survival rate of this group of patients was significantly lower than that of the same stage of colorectal poorly differentiated adenocarcinoma (P <0.05) ). The lymph node metastasis and distant metastasis to neuroendocrine cloning based. Conclusion Colorectal cancer neuroendocrine cloning is an important factor affecting the lymph node metastasis and distant metastasis, it may become a new indicator to determine the prognosis of colorectal cancer and therapeutic targets.