用抗生素治疗感染时,常出现腹泻症状,有时很重,进一步发展时可成为伪膜性结肠炎等药物性结肠炎。其机理被认为是肠内菌群失调,一些正常菌异常增殖所致。有作者曾通过试验认为腹泻的原因是顽固梭状芽胞杆菌产生肠毒素的作用,并从伪膜性结肠炎患者的粪便中检出产生肠毒素能力强的菌株,且分离出 D_1及D_2两种毒素。作者认为诊断该菌引起的腹泻必须证明 With antibiotics to treat infections, often diarrhea symptoms, sometimes heavy, further development can become pseudomembranous colitis and other drug-induced colitis. The mechanism is considered to be intestinal flora, some normal bacteria caused by abnormal proliferation. Some authors have tried to think that the cause of diarrhea is caused by stool Clostridium enterotoxin-producing role and from the stool of patients with pseudomembranous colitis to produce strong enterotoxin-producing strains, and the separation of D_1 and D_2 toxin. The authors believe that the diagnosis of diarrhea caused by the bacteria must prove