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氢化磷脂(HPL)能与水杨酸、双氯灭痛、消炎痛三种非甾体消炎药络合,可以不同比例于氯仿中搅拌几小时,氯仿液呈完全澄清,如含未络合的HPL则仍为混浊分散体。结果说明水杨酸、双氯灭痛、消炎痛与HPL分别为1:1,1:2,1:1(浓度均为50mg/10ml)时可得澄清液。由熔点、红外图谱及差示扫描热量法可显示络合物与物理混合物之不同,表明药物与HPL间发生了络合作用。双氯灭痛和消
Hydrogenated phospholipids (HPL) with salicylic acid, diclofenac sodium, indomethacin three non-steroidal anti-inflammatory drugs complex can be mixed in different proportions of chloroform for a few hours, the chloroform solution was completely clear, such as non-complexed HPL is still Turbid dispersion. The results showed salicylic acid, diclofenac, indomethacin and HPL were 1: 1, 1: 2, 1: 1 (concentrations were 50mg / 10ml) clear solution was obtained. The difference between the complex and the physical mixture can be shown by the melting point, the infrared spectrum and the differential scanning calorimetry, indicating that the drug has complexed with the HPL. Diclofenac and elimination