双膦酸盐(bisphosphonates,BPs)作为一种强效骨吸收作用抑制剂已应用于临床30多年,广泛用于控制与骨更新改变相关疾病的进展,如骨质疏松症、佩吉特骨病、骨转移性癌(多发性骨髓瘤、乳腺癌)等。可以修复骨矿物质密度和骨骼强度[1-2],降低骨折的发生率,极大地提高了患者的生活质量,成 Bisphosphonates (BPs) have been used clinically for more than 30 years as a potent inhibitor of bone resorption and are widely used to control the progression of diseases associated with altered bone turnover such as osteoporosis, Paget’s disease , Bone metastatic cancer (multiple myeloma, breast cancer) and the like. Can repair bone mineral density and bone strength [1-2], reduce the incidence of fractures, greatly improving the quality of life of patients into