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采用HE和特染方法对 8例海洛因成瘾者肾上腺细胞数量和形态变化进行对比研究 .结果表明 ,吸毒 6～ 8a者 ,肾上腺皮、髓质细胞数量均显著减少 ,区域性纤维组织增生 ,慢性炎细胞浸润 ;吸毒 3～4a者 ,皮质细胞灶性坏死 ,髓质细胞数量明显减少 ,胞浆嗜铬颗粒数量和密度降低 ;吸毒 1～ 2a者 ,灶性球状带细胞增生、肥大 ,髓质细胞嗜铬颗粒数量和密度较正常降低 .提示吸毒时限长短与肾上腺细胞病损呈正相关 ,戒毒治疗中应针对性进行治疗
The number and morphological changes of adrenal cells in 8 heroin addicts were compared using HE and special staining methods.The results showed that the number of adrenal and medullary cells was significantly decreased in 6-8 a drug users and the number of regional fibrous tissue hyperplasia and chronic Inflammatory cells infiltration; 3 ~ 4a drug addicts, cortical cells were focal necrosis, the number of medulla cells was significantly reduced, the number and density of cytoplasmic chromaffin particles decreased; 1 ~ 2a drug users, focal spherical zone cell proliferation, hypertrophy, medulla Cell number and density of chromaffin particles decreased more than normal, suggesting that the duration of drug abuse and adrenal cell lesions was positively correlated, drug treatment should be targeted for treatment