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目的 :探讨 Survivin基因表达与宫颈癌发生发展的关系。方法 :应用免疫组化技术 (SP法 ) ,检测Survivin基因在 10例正常宫颈组织、5例上皮内瘤样变及 5 9例宫颈鳞癌中的表达。结果 :Survivin在正常宫颈组织中不表达 ,在宫颈上皮癌变过程中表达阳性率逐级升高。Survivin表达阳性率与宫颈癌的组织学分级和临床分期呈正相关。结论 :Survivin基因表达发生在宫颈癌恶性转化的早期 ,并为宫颈癌预后提供了有价值的判断指标。
Objective: To investigate the relationship between Survivin gene expression and the development of cervical cancer. Methods: The expression of Survivin gene was detected by immunohistochemistry (SP method) in 10 cases of normal cervical tissue, 5 cases of intraepithelial neoplasia and 59 cases of cervical squamous cell carcinoma. Results: Survivin was not expressed in normal cervical tissue, and the expression rate of Survivin increased gradually during carcinogenesis of cervical epithelium. The positive rate of Survivin expression was positively correlated with the histological grade and clinical stage of cervical cancer. Conclusion: Survivin gene expression occurs in the early stage of malignant transformation of cervical cancer, and provides a valuable index for the prognosis of cervical cancer.