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目的:探讨子宫颈透明细胞癌的临床病理特征、免疫组化及与预后的关系。方法:对5例子宫颈透明细胞癌进行组织形态学和免疫组化染色观察,结合文献复习,对其临床病理学及预后进行分析。结果:组织学特征显示瘤细胞较大,胞质丰富而透明,排列成实体巢团、腺管及乳头状结构,可见鞋钉样细胞。免疫标记显示5例瘤细胞CK(+)、CK蛳LMW(+)、CK8(+)、CEA(+),Vim(-)、AFP(-)、ER(-)。特殊染色PAS 5例瘤细胞均(+)。结论:子宫颈透明细胞癌是一种少见的肿瘤,在年龄及组织学上有其特点。其预后与肿瘤的分级、大小、生长方式、核的异型性及核分裂象有密切关系。
Objective: To investigate the clinicopathological features, immunohistochemistry and prognosis of cervical clear cell carcinoma. Methods: Five cases of cervical clear cell carcinoma were observed by histomorphology and immunohistochemistry. Combined with literature review, the clinical pathology and prognosis were analyzed. Results: The histological features showed that the tumor cells were large, the cytoplasm was rich and transparent, and arranged in solid nest, duct and papillary structure. Immunohistochemistry showed CK (+), CK 蛳 LMW (+), CK8 (+), CEA (+), Vim (-), AFP (-) and ER (-) in 5 cases. Special stain PAS 5 cases of tumor cells (+). Conclusions: Cervical clear cell carcinoma is a rare tumor characterized by age and histology. The prognosis and tumor grade, size, growth pattern, nuclear atypia and mitotic phenomenon are closely related.