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研究了苜蓿皂甙降胆固醇作用以及对实验大鼠单核巨噬细胞系统功能的影响。结果表明，与高胆固醇血症组比较，苜宿皂甙可以显著降低实验动物血清ＴＣ和ＬＤＬ－Ｃ（均为Ｐ＜０．０１）。碳粒廓清试验表明，苜蓿皂甙可使校正吞噬指数（α）显著增加（Ｐ＜０．０５），半量清除时间（ｔ）显著缩短（Ｐ＜０．０１）。本研究结果初步提示，苜蓿皂甙降血清胆固醇作用与其增强单核巨噬细胞系统功能有关，应用于家族性高胆固醇血症的治疗可能有效。
The effect of alfalfa saponin on cholesterol lowering and the function of monocyte-macrophage system in experimental rats was studied. The results showed that compared with hypercholesterolemia group, alfalfa saponin can significantly reduce the serum TC and LDL-C of experimental animals (all P <0.01). Carbon clearance test showed that alfalfa saponin significantly increased the corrected phagocytic index (α) (P <0.05) and the half-time clearance time (t) significantly shortened (P <0.01). The results of this preliminary study suggest that the serum cholesterol lowering effect of alfalfa saponin is related to the enhancement of the function of monocyte-macrophage system, and the treatment of familial hypercholesterolemia may be effective.