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目的观察枸橼酸铋雷尼替丁治疗幽门螺杆菌阳性消化道溃疡的效果。方法选择我院2011年3月至2012年3月105例幽门螺杆菌阳性消化道溃疡患者作为观察组,采用枸橼酸铋雷尼替丁三联法(阿莫西林+枸橼酸铋雷尼替丁+甲硝唑)治疗,同时选择105例采用奥美拉唑三联法治疗(阿莫西林+奥美拉唑+甲硝唑)的患者作为对照组。结果观察组总有效率为97.14%;对照组总有效率为96.19%;观察组不良反应发生率为3.81%,对照组为3.81%,两组比较差异无显著性,无统计学意义P>0.05。观察组HP根除率为91.43%;对照组为75.24%,两组比较差异具有显著性(P<0.05)。结论枸橼酸铋雷尼替丁治疗幽门螺杆菌阳性消化道溃疡疗效显著,HP根除率高,且无明显不良反应,可作为临床联合用药的首选。
Objective To observe the effect of ranitidine bismuth citrate in the treatment of Helicobacter pylori positive peptic ulcer. Methods 105 cases of Helicobacter pylori-positive peptic ulcer in our hospital from March 2011 to March 2012 were selected as the observation group, and the ranitidine bismuth citrate triple therapy (amoxicillin + bismuth citrate bismuth ranitidine Ding + metronidazole) treatment, while selecting 105 cases of triple therapy with omeprazole (amoxicillin + omeprazole + metronidazole) patients as a control group. Results The total effective rate was 97.14% in the observation group, 96.19% in the control group, 3.81% in the observation group and 3.81% in the control group, with no significant difference between the two groups (P> 0.05) . In the observation group, the eradication rate of HP was 91.43% and that of the control group was 75.24%. There was significant difference between the two groups (P <0.05). Conclusion Ranitidine bismuth citrate treatment of Helicobacter pylori positive peptic ulcer significant effect, HP eradication rate, and no significant adverse reactions, can be used as the first choice for clinical combination.