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目的观察和评价微卡辅助治疗老年初治菌阳肺结核的疗效。方法将120例老年初治菌阳肺结核病人随机分为治疗组和对照组各60例。对照组采用2HRZE/4HR方案治疗。治疗组采用上述方案治疗的同时,加用微卡22.5μg,臀部肌内注射。每周1次,疗程2个月。然后观察痰菌阴转,肺部病灶吸收、空洞闭合等情况。结果痰菌阴转情况:1个月后治疗组46例,对照组32例,两组比较,差异有非常显著性(P<0·01);2个月后治疗组55例,对照组43例,两组比较,差异有非常显著性(P<0·01);3个月后治疗组60例,对照组58例,两组比较,差异无显著性。病变吸收情况:2、4个月及疗程结束后显效病例,治疗组分别为27、48、52例,对照组分别为14、32、40例,两组比较,差异均有非常显著性(P<0·01)。空洞闭合情况:2、4个月及疗程结束后空洞闭合病例,治疗组分别为11、19、21例,对照组分别为4、13、19例,两组比较,差异均有显著性(P<0·05)。结论微卡辅助治疗老年初治菌阳肺结核有显著性疗效。
Objective To observe and evaluate the curative effect of microcapsule adjuvant therapy for elder onset bacilli and pulmonary tuberculosis. Methods A total of 120 elderly patients with positive bacilli and pulmonary tuberculosis were randomly divided into treatment group (60 cases) and control group (60 cases). The control group was treated with 2HRZE / 4HR regimen. The treatment group using the above treatment at the same time, plus micro-card 22.5μg, buttocks intramuscular injection. Once a week, treatment for 2 months. Then observe sputum negative conversion, absorption of lung lesions, hollow closure and so on. Results sputum negative conversion: one month after the treatment group, 46 cases, 32 cases in the control group, the difference between the two groups was significant (P <0.01); 2 months after the treatment group, 55 cases in the control group 43 Cases, the two groups, the difference was significant (P <0.01); 3 months after the treatment group 60 cases, 58 cases in the control group, the two groups, the difference was not significant. Lesions absorption: 2,4 months and after the end of treatment marked cases, the treatment group were 27,48,52 cases, respectively, the control group were 14,32,40 cases, the two groups, the differences were significant (P <0 · 01). Empty closed cases: 2, 4 months after the end of treatment and empty closed cases, the treatment group were 11,19,21 cases, the control group were 4,13,19 cases, the two groups were significantly different (P <0 · 05). Conclusion Micro-card adjuvant treatment of primary treatment of elderly patients with positive pulmonary tuberculosis have a significant effect.