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目的:探讨胃癌根治术后早期应用帕瑞昔布对患者恢复的影响。方法:选择89例接受胃癌根治术(D2)患者按随机数字表法分为帕瑞昔布组(术后第1天开始应用帕瑞昔布)44例和传统手术组45例。对比两组患者康复相关指标:术后疼痛评分、术后肛门首次排气时间、术后住院时间以及术后并发症发生率。结果:帕瑞昔布组患者术后疼痛评分、肛门首次排气时间和术后住院时间均显著优于传统手术组(P<0.05);帕瑞昔布组患者术后并发症与传统手术组无明显差异(P>0.05)。结论:术后早期应用帕瑞昔布有利于减轻胃癌根治术患者术后疼痛,促进胃肠功能的恢复,减少住院时间,促进患者的快速康复。
Objective: To investigate the effect of early application of parecoxib on the recovery of patients after radical operation of gastric cancer. Methods: Forty-nine patients undergoing radical gastrectomy (D2) were randomly divided into parecoxib group (Parecoxib was started on the first day after operation) and 45 cases in the conventional operation group. Rehabilitation related indicators were compared between the two groups: postoperative pain score, postoperative anal first exhaust time, postoperative hospital stay and postoperative complication rate. Results: The postoperative pain score, the first discharge time of the anus and the postoperative hospital stay in the parecoxib group were significantly better than those in the conventional surgery group (P <0.05). The postoperative complications in the parecoxib group were significantly lower than those in the conventional surgery group No significant difference (P> 0.05). Conclusion: The application of parecoxib in the early postoperative period is beneficial to relieve the postoperative pain, improve the recovery of gastrointestinal function, reduce the hospitalization time and promote the rapid recovery of patients after radical operation.