在一定温度下 ,当脂质膜由凝胶态转变为液晶态时 ,其磷脂的脂酰链紊乱度及活动度增加 ,膜的流动性也增大 ,此时包封的药物释放速率亦增大 ,根据这一原理制备的脂质体称为热敏脂质体 (又称温度敏感脂质体 )。现介绍热敏脂质体在肿瘤热疗中应用的原理以及国内外的研究现状。 At a certain temperature, when the lipid membrane changes from a gel state to a liquid crystalline state, the phospholipid’s fatty acyl chain disorder and activity increase, and the fluidity of the membrane also increases. At this time, the release rate of the encapsulated drug also increases. Large, liposomes prepared according to this principle are called thermosensitive liposomes (also called temperature-sensitive liposomes). The principle of the application of thermosensitive liposomes in hyperthermia therapy and the research status at home and abroad are introduced.