N~1,N~4-二(β-溴丙酰基)-N~2,N~3-二螺三哌嗪(钅翁)二氯化物(Spirobromine)是较近报道的哌嗪类抗肿瘤药物。与其它类型的抗肿瘤药物相比,具有抗肿瘤谱广(见表1),毒性低(LD_(50)1924mg/kg)等优点。因此,有潜在的研究价值。本文对该类化合物的合成,生理活性及构 N ~ 1, N ~ 4-Bis (β-bromopropionyl) -N ~ 2, N ~ 3-spirobistripiperazine (Spirobromine) is a recently reported piperazine anti-tumor drug. Compared with other types of anti-tumor drugs, it has many advantages such as wide anti-tumor spectrum (see Table 1), low toxicity (LD_ (50) 1924mg / kg) Therefore, there is potential research value. This article on the synthesis of these compounds, physiological activity and structure