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现代肿瘤学认为遗传物质的改变在垂体腺瘤的发生、发展过程中起着重要作用。目前研究认为7、8、12、X等染色体的获得可能参与其启动阶段,而11、13等染色体丢失可能与肿瘤发展及侵袭性生长密切相关。另外,Gsp、Ras等原癌基因突变,Rb、p53、MEN-l等抑癌基因灭活与垂体腺瘤发病关系较为密切。
Modern oncology that genetic material changes in the occurrence and development of pituitary adenoma plays an important role. The current study suggests that 7, 8, 12, X and other chromosomes may be involved in the start-up stage of the acquisition, and 11, 13 and other chromosome loss may be closely related to tumor development and invasive growth. In addition, mutations such as Gsp, Ras and other proto-oncogenes, inactivation of tumor suppressor genes such as Rb, p53 and MEN-1 are closely related to the pathogenesis of pituitary adenomas.