多发性骨髓瘤常在老年发生,40岁以下不到5%,小于25岁者更为罕见。特别在青年患者,临床过程较老年和15岁以下为佳。本文报告2例男性青年骨髓瘤,病程相对延缓而好,对其骨髓浆细胞的电镜特点作了描述。例1为19岁男性,于1961年踢足球时出现短暂颈痛,2年后因车祸发现C_5及C_4椎体塌陷伴溶骨性改变,作椎体融合术。1964年全C_5被巨大浆细胞瘤占据,并向邻近C_4及C_6扩展,切除肿瘤并再作椎体融合术,由于骨骼及骨髓检查正常,血或尿中无副蛋 Multiple myeloma often occurs in the elderly, less than 5% under the age of 40, less than 25 years of age are even more rare. Especially in young patients, the clinical course is better than older and under 15 years of age. This article reports 2 cases of young male myeloma, the course is relatively slow and good, described the electron microscopy of bone marrow plasma cells. Example 1: A 19-year-old man with a transient neck pain when playing football in 1961. Two years later, he found a vertebral body fusion with C 5 and C 4 collapse and osteolytic changes. In 1964, C_5 was occupied by the plasmacytoma and extended to adjacent C_4 and C_6. The tumor was resected and vertebral fusion was performed. Due to the normal bone and bone marrow examination, there was no accessory egg in blood or urine