多发性硬化症(multiple sclerosis,MS)是一种慢性中枢神经系统退行性疾病,其特征是局灶性的炎性反应、脱髓鞘、炎细胞浸润、少突胶质细胞的死亡和轴突损害。尽管MS的明确病因尚不清楚,有证据认为谷氨酸的兴奋性神经毒性涉及病理过程。MS通常始于鞘磷脂的自身免疫反应,后期进展 Multiple sclerosis (MS) is a chronic central nervous system degenerative disease characterized by focal inflammatory responses, demyelination, inflammatory cell infiltration, oligodendrocyte death and axons damage. Although the exact etiology of MS is not clear, there is evidence that excitotoxicity of glutamate involves pathological processes. MS usually begins with the sphingomyelin autoimmune response, late progression