中药“十八反”是本草配伍禁忌理论的一个重要内容,是古代医家长期临床实践经验的总结,其内容在明清时期更加趋于统一,这种经验总结在一定程度上保障了临床用药的安全。通过梳理明清本草和医案著作,发现明清医家对中药“十八反”禁忌理论总体上继承,同时又在临床应用中提出了自己的见解,如王道和霸道理论、相反相激理论等,进一步丰富了中药“十八反”配伍禁忌的内涵。 Chinese medicine “Eighteen anti” is an important part of Materia Medica incompatibility theory, is a summary of the ancient physicians long-term clinical experience, its content tends to be more unified in the Ming and Qing Dynasties, this experience concluded to a certain extent, to protect the clinical Medication safety. By combing Ming and Qing Materia Medica and medical records, it was found that Ming and Qing physicians generally inherit the taboo theory of traditional Chinese medicine and eighteen anti-contractions, and at the same time put forward their own opinions in clinical application such as Wang Daowu and overbearing theory. On the contrary, Theory, etc., further enriched the connotation of traditional Chinese medicine “eighteen anti-” incompatibility.