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目的:观察脑苷肌肽治疗小儿病毒性脑炎的临床疗效。方法:将100例病毒性脑炎的患儿随机分为2组。每组50例,治疗组在常规治疗基础上给予脑苷肌肽注射液2mg(0~3岁),4mg(~14岁);对照组给予胞磷胆碱钠,0.125(0~3岁),0.25(~14岁)均加入5%葡萄糖50-100ml中静脉滴注,每天一次,疗程7-10天。比较两组间患儿发热、头痛、抽搐、意识障碍、脑膜刺激征、病理征、精神症状、肢体瘫痪恢复时间。治疗组患儿抽搐、意识障碍、巴氏征、肢体瘫痪恢复时间明显优于对照组。(P<0.05);发热、头痛、神经症状恢复时间与对照组比较无明显差异(P>0.05)。结果:治疗组、对照组均无严重不良反应发生。结论:脑苷肌肽治疗重症病毒性脑炎有良好的临床疗效,且安全性较好。
Objective: To observe the clinical efficacy of cerebroside in the treatment of pediatric viral encephalitis. Methods: 100 children with viral encephalitis were randomly divided into two groups. (N = 50). The treatment group was given 2mg (0-3 years old) and 4mg (~ 14 years old) of NS on the basis of routine treatment. The control group was given citicoline sodium 0.125 (0-3 years old) 0.25 (~ 14 years) were added 5% glucose 50-100ml intravenous infusion, once daily, the course of 7-10 days. The fever, headache, convulsions, disturbance of consciousness, meningeal irritation, pathological signs, mental symptoms and limb paralysis recovery time were compared between the two groups. Treatment group children with convulsions, disturbance of consciousness, Pakistan’s sign, limb paralysis recovery time was significantly better than the control group. (P <0.05). There was no significant difference in recovery time of fever, headache and neurological symptoms between the two groups (P> 0.05). Results: The treatment group and the control group had no serious adverse reactions. Conclusion: Cerebroside glycoside treatment of severe viral encephalitis has a good clinical efficacy, and safety is good.