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[目的]探讨部分脾动脉栓塞术(PSE)治疗肝硬化门静脉高压症的临床疗效及安全性。[方法]对48例不同原因肝硬化门静脉高压患者行PSE治疗,观察术前及术后1周、1、3、6个月血常规、肝功能、脾脏厚度、脾静脉和门静脉内径、Child-Pugh分级变化及并发症情况。[结果]PSE后患者白细胞和血小板计数均明显升高(P<0.01);术后1个月患者脾静脉和门静脉内径明显缩小(P<0.05,P<0.01),术后6个月脾脏厚度明显缩小(P<0.05);术后患者凝血酶原时间缩短(P<0.01),总胆红素升高(P<0.01),但谷草转氨酶、谷丙转氨酶及ChildPugh分级变化PSE前、后差异无统计学意义(P>0.05);PSE后并发症较多,但未发现严重的并发症。[结论]PSE治疗肝炎肝硬化门静脉高压症合并脾功能亢进安全有效。
[Objective] To investigate the clinical efficacy and safety of partial splenic arterial embolization (PSE) in the treatment of liver cirrhosis and portal hypertension. [Methods] Forty-eight patients with portal hypertension caused by cirrhosis of the liver were treated with PSE. The blood routine, liver function, spleen thickness, splenic vein and portal vein diameter before operation, 1 week, 1, Pugh classification changes and complications. [Results] The numbers of white blood cells and platelets in patients with PSE were significantly increased (P <0.01). The diameter of splenic vein and portal vein was significantly reduced at 1 month after operation (P <0.05, P <0.01) (P <0.01), and total bilirubin increased (P <0.01). However, the changes of AST, ALT and Child Pugh scores before and after PSE were significantly different No statistical significance (P> 0.05); PSE after more complications, but no serious complications were found. [Conclusion] PSE is safe and effective in the treatment of hepatic cirrhosis and portal hypertension with hypersplenism.